Southeast Missouri Vacation Packages
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Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
Top Southeast Missouri Vacation Deals
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Price was CA $1,284, price is now CA $1,000 per person
CA $1,000
per person
Dec 18 - Dec 20
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
9.2/10 Wonderful! (1,677 reviews)
Everything was good. Seemed that the property was not full but we were forced into a suite.
Reviewed on Nov 7, 2026
Moonrise Hotel
Delmar Loop
Price was CA $2,091, price is now CA $1,735 per person
CA $1,735
per person
Dec 16 - Dec 23
found 3 hours ago
Roundtrip flight included
Toronto (YYZ) to St. Louis (STL)
9/10 Wonderful! (2,047 reviews)
Moonrise is a quirky and unique hotel in a great neighborhood. I will gladly stay there again in the future.
Reviewed on Nov 9, 2026
Ameristar Casino Resort and Spa
Price was CA $2,151, price is now CA $1,809 per person
CA $1,809
per person
Dec 16 - Dec 23
found 3 hours ago
Roundtrip flight included
Toronto (YYZ) to St. Louis (STL)
8.6/10 Excellent! (1,080 reviews)
We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel.
Reviewed on Nov 8, 2026
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $141 per night from Nov 13 to Nov 14
CA $141
CA $159 total
Nov 13 - Nov 14
includes taxes & fees
Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Dec 6 to Dec 7
CA $126
CA $141 total
Dec 6 - Dec 7
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is CA $77 per night from Nov 15 to Nov 16
CA $77
CA $88 total
Nov 15 - Nov 16
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southeast Missouri attractions
What to do in Southeast Missouri
Night Ghost Tour of Pythian Castle in Springfield Missouri
CA $28
per adult
96% of travellers recommend
Tour The Ozarks Private Springfield Brewery Tour
CA $302
per adult
Frequently asked questions
Explore a world of travel with Expedia
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- Essex Hotels
- Farmstay in Oak Ridge
- Cottages in Clearwater
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- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- Cabin Rentals in Centerville
- Holiday Inn Poplar Bluff by IHG
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Advance Hotels
- Fredericktown Hotels
- Cabin Rentals in Cadet
- Pickleball Cafe & Micro Hotel
- Quality Inn Perryville I
- Secluded Cabin with Heated Pool
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Cheap Hotels in Bonne Terre
- Relax in the country at Countryside Villas!
- Bonne Terre Hotels
- Hilton Hotels in Perryville
- Bluebird Meadows W/hot Tub and Pool Special
- Houseboats in Wappapello
- Cabin Rentals in Leadwood
- Condo Rentals in Fremont
- Scott City Hotels
- The Weber Farm
- Spring Lake Ranch has a Private
- Cottages in Pocahontas
- B&B in Ste Genevieve
- Cabin Rentals in Southeast Missouri
- Hampton Inn Poplar Bluff
- The Queen Bee Farm Stay/Hot tub
- Postcard Cabins St Francois
- Cabin Rentals in Allenville
- Van Buren Hotels
- Secluded Private Cabin with Pool
- Villas in Poplar Bluff
- Rv Parks in Chaffee
- Triangle Inn Motel
- Bullwinkles Rustic Lodge
- Pet-Friendly Hotels in Jackson
- Apartments in Ozora
- Silo Farm Haus
- Jackson Hotels
- Dexter Hotels
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Dexter Inn
- Town House Inn
- Oyo Hickory House Inn
- Resorts in Wayne County
- Cheap Hotels in Viburnum
- Hilton Hotels in Ste Genevieve
- Cabin Rentals in Farmington
- Hotels near Big River
- Crown Pointe Lodge
- Motels in Ellsinore
- Poplar Bluff Hotels
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Cabin Rentals in Bonne Terre
- Park Hills Hotels
- French Village Hotels
- Flights from New York (JFK) to Cape Girardeau (CGI)
- Flights from Colombo (CMB) to Cape Girardeau (CGI)
- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights to Poplar Bluff
- Flights from Vancouver (YVR) to Cape Girardeau (CGI)
- Flights to Farmington
- Flights from Bloomington (BMI) to Cape Girardeau (CGI)
- Flights from Toronto (YTO) to Cape Girardeau (CGI)
- Flights from Grand Island (GRI) to Cape Girardeau (CGI)
- Flights to Bonne Terre
- Flights from Bonne Terre
- Flights from Stuart (SUA) to Cape Girardeau (CGI)
- Flights from Arcadia
- Flights from Chaffee
- Flights from Belleview
- Flights from Calgary (YYC) to Cape Girardeau (CGI)
- Flights to Butler County
- Flights from Toronto (YYZ) to Cape Girardeau (CGI)
- Flights from Edmonton (YEG) to Cape Girardeau (CGI)
- Flights from Montreal (YUL) to Cape Girardeau (CGI)
- Flights to Dexter
- Flights from Eugene (EUG) to Cape Girardeau (CGI)
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Ocala (OCF) to Cape Girardeau (CGI)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
