Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

CA $1,030
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9.2/10 Wonderful! (1,672 reviews)
Staff were so helpful and an initiating. Used this hotel as a stop over. I was pleasantly surprised.

Reviewed on Aug 10, 2026

The Cheshire

The Cheshire

CA $1,172
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
8.8/10 Excellent! (1,006 reviews)
When checking in, the staff woman was less than friendly. There seemed to be a situation with another upset guest that may have caused the unpleasant nature. Once we entered the room, we noticed right away a musty smell. The AC did not seem to be working correctly. Though it never got hot, it also never got any cooler. The furniture had visible stains and a few of the pillow cases had staining as well. The pillows themselves are downed pillows and once you lay on them, they flatten out thin. We requested a few extra pillows that were supposed to be brought to our room which never arrived. We requested more towels which were also supposed to be brought to our room which also never arrived. Breakfast on morning one for us which was Sunday was great, however it was apparent that the fruit and pastries were being reused daily and by our check out morning on Tuesday they were no good. The pool area was decent. You have to reserve the canopy so it was unusable to us. Overall, our stay was okay. I wouldn’t say it was awful but I wouldn’t say it was great either. We don’t intend on staying in the future.

Reviewed on Aug 9, 2026

 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

Central West End
CA $1,453
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9/10 Wonderful! (1,015 reviews)
Beautiful hotel and great location.

Reviewed on Aug 10, 2026

Moonrise Hotel

Moonrise Hotel

Delmar Loop
CA $1,163
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9/10 Wonderful! (2,006 reviews)

Ready to book your vacation to Southeast Missouri?

Choose your dates

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
CA $139
CA $157 total
Aug 16 - Aug 17
includes taxes & fees
9.6/10 Exceptional! (1,016 reviews)
"Everything about this property is 1000000/100000"

Reviewed on Aug 9, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
CA $79
CA $86 total
Aug 18 - Aug 19
includes taxes & fees
8/10 Very good! (1,012 reviews)
"Yes"

Reviewed on Aug 10, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
CA $147
CA $165 total
Aug 16 - Aug 17
includes taxes & fees
The Riverview
See all 675 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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What to do in Southeast Missouri

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

CA $28
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

CA $218
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just CA $1,030. Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.