Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
Downtown West
Price was CA $1,021, price is now CA $853 per person
CA $853
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8/10 Very Good! (502 reviews)
Loved the historical property and surrounding historical activities.

Reviewed on Aug. 23, 2025

The Cheshire

The Cheshire

4 out of 5
Price was CA $1,110, price is now CA $919 per person
CA $919
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.6/10 Excellent! (1,001 reviews)
Old property but has some real charm. The breakfast is outstanding and good location near park.

Reviewed on Sep. 3, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was CA $1,092, price is now CA $918 per person
CA $918
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.8/10 Excellent! (1,017 reviews)
The property was excellent with all the art in the building. Be staff was excellent and very friendly, caring and accommodating.

Reviewed on Aug. 25, 2025

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
Price was CA $1,047, price is now CA $885 per person
CA $885
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.2/10 Very Good! (1,000 reviews)
Parking is terrible and you shouldn’t have to pay $15 to park then charge for breakfast when your paying all that money to stay!!

Reviewed on Aug. 23, 2025

Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
Edmundson
Price was CA $1,224, price is now CA $1,035 per person
CA $1,035
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
7.8/10 Good! (1,001 reviews)
I will definitely come back

Reviewed on Sep. 1, 2025

Ready to book your vacation to Southeast Missouri?

 

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Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is CA $74 per night from Sep 14 to Sep 15
CA $74
CA $84 total
Sep 14 - Sep 15
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Sep 14 to Sep 15
CA $124
CA $140 total
Sep 14 - Sep 15
includes taxes & fees
Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is CA $145 per night from Sep 7 to Sep 8
CA $145
CA $164 total
Sep 7 - Sep 8
includes taxes & fees
The Riverview
See all 600 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Southeast Missouri

Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Century Casino Caruthersville

What to do in Southeast Missouri

St Louis: City Museum General Admission Ticket

St Louis: City Museum General Admission Ticket

CA $31
per adult
96% of travellers recommend
St Louis: City Museum General Admission Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

CA $33
per adult
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
St Louis: 75-Minute City Trolley Tour

St Louis: 75-Minute City Trolley Tour

CA $41
per adult
St Louis: 75-Minute City Trolley Tour
See all activities in Southeast Missouri
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.