Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was CA $1,119, price is now CA $968 per person
CA $968
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Toronto (YTO) to St. Louis (STL)
8.8/10 Excellent! (1,065 reviews)
Cleaning needs help in the rooms and bathrooms. Room 511 hopefully is the smallest of all the rooms. You couldn’t use the chair fully with the desk and had to take turns in areas it was so tight. The staff was wrong about times for the Terrance bar and restaurant causing us to wait for that and then miss the downstairs restaurant being open so we waited a few more hours to find a place to eat. Simple mistake but that’s their job.

Reviewed on Mar 22, 2026

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was CA $1,487, price is now CA $1,277 per person
CA $1,277
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Toronto (YTO) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

The Cheshire

The Cheshire

4 out of 5
Price was CA $1,165, price is now CA $1,007 per person
CA $1,007
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Toronto (YTO) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
Very friendly staff. Reasonable price drinks

Reviewed on Mar 22, 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was CA $1,190, price is now CA $1,034 per person
CA $1,034
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Toronto (YTO) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
Overall it was a positive experience but we were VERY disappointed when we found out our daughter couldn’t swim all weekend. We would not have booked it if we had known that.

Reviewed on Mar 22, 2026

Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
Edmundson
Price was CA $1,300, price is now CA $1,135 per person
CA $1,135
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Toronto (YTO) to St. Louis (STL)
8/10 Very Good! (1,003 reviews)
The toilet had a leak and even though it said it was a 4 star, other than the bar, i only saw three stars

Reviewed on Feb 21, 2026

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Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $137 per night from Mar 29 to Mar 30
CA $137
CA $155 total
Mar 29 - Mar 30
includes taxes & fees
9.6/10 Exceptional! (1,010 reviews)
Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in.

Reviewed on Mar 20, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $156 per night from Mar 26 to Mar 27
CA $156
CA $177 total
Mar 26 - Mar 27
includes taxes & fees
9.4/10 Exceptional! (532 reviews)
The young man that checked me in did not have a welcoming personality nor seemed to care about any of my questions. He was very flat and inattentive.

Reviewed on Mar 23, 2026

The Riverview
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $129 per night from Mar 29 to Mar 30
CA $129
CA $148 total
Mar 29 - Mar 30
includes taxes & fees
9.4/10 Exceptional! (1,005 reviews)
Always a good value. Nice and quiet. Comfortable beds.

Reviewed on Mar 23, 2026

Drury Inn & Suites Sikeston, MO
See all 626 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Southeast Missouri

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Century Casino Caruthersville

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

What to do in Southeast Missouri

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

CA $27
per adult
100% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

CA $213
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travelers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your vacation savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks traveling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.